Research

For the most current list of publications see Pubmed or Google Scholar

The Neurobiology of Postpartum Depression and Anxiety

JL Pawluski, JS Lonstein,

AS Fleming

Trends Neurosci. 2017 Feb;40(2):106-120. doi: 10.1016/j.tins.2016.11.009. Epub 2017 Jan 24.

Much of my early research has focused on understanding how motherhood impacts hippocampal plasticity, cognition, and related physiology in the maternal brain. Over the past decade I have expanded this research program to focus on how stress and antidepressant medications during the perinatal period alter maternal brain, behavior and offspring outcomes.  I work with both animal models and clinical populations.

Details: Currently my research is affiliated with the Irset (Institut de recherche en santé, environnement et travail) at the Universite de Rennes 1, France. I do research in the group headed by Prof Thierry Charlier and continue to mentor undergraduate and graduate students. I have over 60 scientific publications in peer-reviewed journals and regularly present my research findings at national and international conferences. My research has been supported by funding from agencies such as the Brain and Behavior Reserach Foundation (NARSAD 2015) and Fonds de la Recherche Scientifique (Belgique) and presently is funded by Institut des Neurosciences Cliniques de Rennes (INCR). I am on the editorial board for Archives of Women’s Mental Health (Springer), Journal of Neuroendocrinology (Wiley), and Journal of Chemical Neuroanatomy Elsevier). I'm also a Fellow of the International Behavioral Neuroscience Society. 

Publications (2017- ):

  1. JL Pawluski, R Paravatou, A Even,  G Cobraiville, M Fillet, N Kokras, C Dalla, T Charlier (2020). Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats. Neuropharmacology. Jan 11;166:107950. doi: 10.1016/j.neuropharm.2020.107950. [Epub ahead of print] PMID: 31935392

  2. Martin B, Dieuset G, Pawluski JL, Costet N, Biraben A. (2020). Audiogenic seizure as a model of sudden death in epilepsy: A comparative study between four inbred mouse strains from early life to adulthood. Epilepsia. 2020 Jan 24. doi: 10.1111/epi.16432. [Epub ahead of print]. PMID: 31981213

  3. Dechartres J, Pawluski JL, Gueguen MM, Jablaoui A, Maguin E, Rhimi M, Charlier TD. Glyphosate and glyphosate-based herbicide exposure during the peripartum period affects maternal brain plasticity, maternal behaviour and microbiome. J Neuroendocrinol. 2019 [Epub ahead of print]

  4. Lumineau S, Pawluski JL, Charlier TD, Beylard A, Aigueperse N, Bertin A, Lévy F. (in press) High social motivation induces deficits in maternal behavior but not plasticity of the subventricular zone in Japanese quail (Coturnix japonica). J Neuroendocrinol. 2019 Mar 29:e12716. doi: 10.1111/jne.12716. [Epub ahead of print]

  5. Pawluski JL*, Brain U, Hammond GL, Oberlander TF. (2019) Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression. Arch Womens Ment Health. 2018 Dec 1. doi: 10.1007/s00737-018-0931-1. [Epub ahead of print]

  6. Gemmel M, De Lacalle S, Mort SC, Hill LA, Charlier TD, Pawluski JL* (2019). Perinatal fluoxetine has enduring sexually differentiated effects on neurobehavioral outcomes related to social behaviors. Neuropharmacology. 2018 Oct 13;144:70-81. doi: 10.1016/j.neuropharm.2018.10.009. IF 4.249

  7. Pawluski JL, Kuchenbuch M, Hadjadj S, Dieuset G, Costet N, Vercueil L, Biraben A, Martin B. (2018). Long-term negative impact of an inappropriate first antiepileptic medication on the efficacy of a second antiepileptic medication in mice. Epilepsia. 2018 Jul;59(7):e109-e113. doi: 10.1111/epi.14454. Epub 2018 Jun 14. IF 5.067

  8. Gemmel M, Harmeyer D, Bögi E, Fillet M, Hill LA, Hammond GL, Charlier TD, Pawluski JL* (2018). Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam. Feb 26;339:222-231. Behavioural Brain Research. IF 3.173

  9. Gemmel M, Kokras N, Dalla C, Pawluski JL* (2018). Perinatal fluoxetine prevents the effect of pre-gestational maternal stress on 5-HT in the PFC, but maternal stress has enduring effects on mPFC synaptic structure in offspring. Neuropharmacology. Jan;128:168-180. IF 4.249

  10. Gemmel M, Hazlett M, Bögi E, De Lacalle S, Hill LA, Kokras N, Hammond GL, Dalla C, Charlier TD, Pawluski JL* (2017) Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress. Psychoneuroendocrinology. 2017 Oct;84:159-171. doi: 10.1016/j.psyneuen.2017.07.480. IF4.731

Review Articles (2017- )

  1. Pawluski JL*, Li M, Lonstein JS. (2019). Serotonin and motherhood: From molecules to mood. Front Neuroendocrinol. 2019 Mar 13. pii: S0091-3022(18)30064-5. doi: 10.1016/j.yfrne.2019.03.001. [Epub ahead of print] Review.

  2. Dickens MJ and Pawluski JL* (2018) The HPA Axis During the Perinatal Period: Implications for Perinatal Depression. Endocrinology. 2018 Nov 1;159(11):3737-3746. doi: 10.1210/en.2018-00677. IF 3.963

  3. Gemmel, M and Pawluski, JL* (2018). Perinatal SSRI medications and offspring hippocampal plasticity: interaction with maternal stress and sex. Hormones. Mar;17(1):15-24. Invited minireview. IF1.10

  4. Hutchison SM, Mâsse, LC, Pawluski, JL, Oberlander TF (2018). Perinatal Selective Serotonin Reuptake Inhibitor (SSRI) Effects on Body Weight at Birth and Beyond: A Review of Animal and Human Studies. Apr;77:109-121. Reproductive Toxicology. IF 2.580

  5. Gemmel M, Bögi E, Ragan C, Hazlett M, Dubovicky M, van den Hove DL, Oberlander TF, Charlier TD, Pawluski JL* (2017). Perinatal selective serotonin reuptake inhibitor medication (SSRI) effects on social behaviors, neurodevelopment and the epigenome. Neurosci Biobehav Rev. Feb;85:102-116. IF8.037

  6. Pawluski JL*, Lonstein JS, Fleming AS. (2017). The Neurobiology of Postpartum Anxiety and Depression. Trends Neurosci. 40(2):106-120.  IF11.439    

 

Editorials/Letters to the Editor

  1. Pawluski JL, Champagne FA, Bosch OJ.(2019) Parental Brain Conference 2018. J Neuroendocrinol. 2019 Sep 5. doi: 10.1111/jne.12789.

  2. Pawluski J, Dickens M. (2019) Pregnancy: a final frontier in mental health research. Arch Womens Ment Health. 2019 Jul 9. doi: 10.1007/s00737-019-00988-y.

  3. Pawluski JL. (2019) The Neurobiology of Maternal Mental Illness: Current understanding and future directions. Arch Womens Ment Health. 2019 Jun;22(3):407-408. doi: 10.1007/s00737-019-00969-1.

  4. Pawluski JL*, Lonstein JS, Fleming AS (2017). Neglected Neurobiology of Maternal Mental Illness. Science & Technology News. Pan European Networks. Issue 22: 155-157.

  5. Pawluski JL*, Lonstein JS, Fleming AS (2017). Neglected Neurobiology of Maternal Anxiety and Depression. The Neuropsychotherapist Magazine. http://www.neuropsychotherapist.com/the-neglected-neurobiology-of-maternal-anxiety-and-depression/

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© 2020 by Dr. Jodi Pawluski